Command
reg add “HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer” /v SmartScreenEnabled /t REG_SZ /d Off /f /reg:64
Intune – Device Configuration Profile
MS Intune > Device configuration > Profile > Create profile > Name > Windows 10 and later > Profile type Endpoint Protection > click Create button > Name > Description > click on Microsoft Defender SmartScreen > select Not Configured > OK > OK > click Create button > Assign
Notes
https://docs.microsoft.com/en-us/mem/intune/protect/endpoint-protection-windows-10